Cisplatin pten

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August undefined, 2024

WebCisplatin / pharmacology Cyclin-Dependent Kinase Inhibitor p27 / metabolism Drug Synergism Female Gene Expression Regulation, Neoplastic / drug effects Humans Intracellular Signaling Peptides and Proteins / antagonists & inhibitors Intracellular Signaling Peptides and Proteins / genetics* Intracellular Signaling Peptides and Proteins / … WebFeb 16, 2024 · Generic name: cisplatin [ sis-PLA-tin ] Brand names: Platinol, Platinol-AQ, Platinol (Restricted Access) Dosage forms: intravenous powder for injection (50 mg), …

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WebSep 15, 2024 · DESCRIPTION. Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL … WebJul 5, 2024 · Another in vivo study showed a synergistic effect of Cisplatin used in combination with the CK2-targeting compound CIGB-300, in nude mice xenografted with human cervical tumor cells, and an increased mice survival compared to single-agent treatment was observed [].The rationale of targeting CK2 in combination with Cisplatin … opel crossland fiyat

Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA ... - PubMed

WebMay 10, 2024 · Although cisplatin (Cis) is an effective chemotherapeutic agent in treatment of various cancers, its adverse effect of nephrotoxicity limits the clinical application. Remote ischemic preconditioning (RIPC) is a strategy to induce resistance in a target organ against the oxidative stress and injury by applying transient, brief episodes of ischemia. WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … iowa greyhound park results

IJMS Free Full-Text NHERF1 Enhances Cisplatin Sensitivity in …

miR-205-5p Mediated Downregulation of PTEN Contributes to Cisplatin …

WebPRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage. Data files. Show entries ... neurons (SGNs) are auditory neurons that relay sound signals from the inner ear to the brainstem. The ototoxic drug cisplatin can damage SGNs and thus lead to sensorineural hearing … WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … opel crossland elegance 2021WebSpiral ganglion neurons (SGNs) are auditory neurons that relay sound signals from the inner ear to the brainstem. The ototoxic drug cisplatin can damage SGNs and thus lead to sensorineural hearing loss (SNHL), and there are currently no methods for preventing or … iowa greyhound stats

"WebMar 22, 2024 · Diaminodichloroplatinum (cisplatin, DDP) is one of the most effective and widely used DNA-damaging anticancer drugs used for the treatment of various human malignancies including NSCLC [ 4 ]. However, NSCLC patients who are initially sensitive to cisplatin often develop drug resistance, leading to chemotherapy failure [ 5 ]. " - Cisplatin pten

Cisplatin pten

Synergistic Effect of Olaparib with Combination of Cisplatin on PTEN …

WebFeb 1, 2013 · We hypothesize that PTEN -deficient lung cancer cells suppressed DNA damage signaling and that the absence of PTEN can sensitize these cells to a concurrent treatment of a DNA-damaging agent (cisplatin) and a PARP inhibitor (olaparib). WebSep 18, 2024 · NCBI Bookshelf

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WebSep 24, 2024 · The main lipid substrate of PTEN is PIP 3 and indeed PTEN acts as a negative regulator of PI3K/AKT signaling. ... Wu, D. M. et al. The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance ... WebJan 12, 2024 · Cervical cancer is one of the most common female malignancies, and cisplatin-based chemotherapy is routinely utilized in locally advanced cervical cancer patients. However, resistance has been the major limitation. In this study, we found that Na+/H+ Exchanger Regulatory Factor 1 (NHERF1) was downregulated in cisplatin …

WebAug 27, 2024 · Plasmids PTEN-shRNA and PTEN-NC, which contain green fluorescent protein (GFP) and anti-puromycin genes, were extracted from glycerol bacteria and purified according to the manufacturer’s protocols. GC cells were cultured in DMEM/F-12 with 10% FBS in 6-well plates until they reached 70%–80% confluence. WebThis is the case of vesicular miR-21 that induced cisplatin resistance in oral squamous cell carcinoma by targeting phosphatase and tensin homolog (PTEN) and programmed cell death protein 4 (PDCD4), which are tumor suppressors involved in apoptosis, cell transformation, invasion, and tumor progression .

WebApr 25, 2024 · In this study, we investigate the role of miRs and PTEN in renoprotective effect of curcumin against cisplatin-induced AKI in mice. It is aimed to reveal the mechanism of curcumin which protected the kidney and provided evidence on the therapeutic application of curcumin in alleviating AKI. Go to: Materials and methods Drugs WebNov 19, 2024 · Cisplatin is an anti-cancer chemotherapy drug which used to treat ovarian cancer in women who have already received surgery and/or radiation treatment. …

WebApr 13, 2024 · HIGHLIGHTS who: Florentine S. B. Subtil et al. from the Department of Radiotherapy and Radiooncology, Philipps-University, Marburg, Germany have published the research: Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic … Dual pi3k/mtor inhibitor nvp-bez235 leads to a synergistic enhancement of cisplatin and …

WebSep 28, 2007 · We report that EF24, a synthetic compound 3,5-bis (2-flurobenzylidene)piperidin-4-one, greatly inhibits cisplatin-resistant (CR) human ovarian cancer cell proliferation. The inhibitory effect of EF24 on cell proliferation is associated with G (2)/M phase cell cycle arrest and increased G (2)/M checkpoint protein (pp53, p53, … opel crossland hybrid plug inWebJul 26, 2013 · In the cytoplasm, PTEN antagonizes the phosphatidylinositol 3-kinase (PI3K) signaling pathway. PTEN also accumulates in the nucleus, where its function remains poorly understood. We demonstrate that SUMOylation (SUMO, small ubiquitin-like modifier) of PTEN controls its nuclear localization. opel crossland hybride prixWebBackground: Platinum-based chemotherapy, cisplatin (DDP) specifically, is the main strategy for treating lung cancer (LC). However, currently, there is a lack of predictive drug-resistance markers, and there is increased interest in the development of a reliable and sensitive panels of markers for DDP chemotherapy-effectiveness prediction. MicroRNAs … iowa grocers associationWebSep 2, 2024 · Gene therapy aims to silence an oncogene through RNA interference, or replace an abnormal tumour suppressor via gene augmentation. In this study, we intended RNA interference for PRKCA oncogene and gene augmentation for PTEN tumour suppressor with a view to reduce tumour growth in a mouse model of breast cancer. … opel crossland gsWebFeb 7, 2014 · PTEN, a tumor suppressor gene, has been demonstrated to be able to reverse cisplatin-resistance in ovarian cancer cell line C13K. However, the downstream … opel crossland leasingangeboteWebApr 10, 2024 · Indeed, PTEN serves as a dual-specific phosphatase that suppresses cell proliferation and induces apoptosis and cell cycle arrest via repressing PI3K/Akt signaling mechanisms [208]. Zheng et al. revealed that miR-24 increases the chemoresistance of human TSCC cell lines to cisplatin by downregulating PTEN [209]. opel crossland innovationWebMay 17, 2024 · Cisplatin is a bifunctional platinum (II) complex with two chloride leaving ligands. The monofunctional platinum (II) complex, phenanthriplatin, has one chloride leaving ligand, and steric bulk... opel crossland leasing