Ctgf knockout mice viable
WebNov 17, 2024 · Connective tissue growth factor (CTGF/CCN2) regulates the signalling of other growth factors and promotes fibrosis. CTGF is increased in mice and humans with peritoneal fibrosis. Inhibition of CTGF has not been examined as a potential therapeutic target for peritoneal fibrosis because systemic CTGF knockout mice die at the perinatal … WebThe capacity of CTGF to interact with different growth factors lends an important role during early and late development, especially in the anterior region of the embryo. CTGF …
Ctgf knockout mice viable
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WebOct 14, 2014 · A 50% reduction in CTGF expression by antisense oligonucleotides attenuated the progression of CKD and fibrosis after unilateral ureteral obstruction (UUO) … WebPurpose: This study aimed to elucidate the role of connective tissue growth factor (CTGF) in healthy eyes and wounded corneas of mice and rabbits. Conditional knockout mice …
WebApr 1, 2014 · Since the CTGF expression data between the rabbit and mouse epithelia were comparable, we considered the use of a CTGF knockout mouse as a feasible model to test CTGF's role in wound healing. Dosing ubc-Cre/CTGF floxed/floxed mice ( Figs. 4 A, A,4B) 4 B) with tamoxifen is sufficient to cause recombination-mediated removal of exon 4 ( Fig. …
WebMay 13, 2024 · Conditional knockout of LATS1 and LATS2 (LATS1/2) in mouse liver increases proliferation and represses the maturation of hepatocytes thereby causing pre-natal lethality 17. Whether or not LATS1/2 ... WebNov 13, 2024 · Importantly, we can now report that our CRISPR-Cas9-generated TFPIγ KO strains - TFPIαβ mice, TFPIα only mice, and TFPIβ only mice are viable and reproduce. To illustrate the potential influence of TFPIγ in a mouse model, we used a tail vein-rebleeding assay to assess bleeding in TFPI isoform-specific mice in a FVIII KO background.
WebJul 7, 2016 · To investigate the impact of Klf5 loss in hematopoiesis, we generated a conditional Klf5 gene ablation model (Klf5 Δ/Δ mice) using the well-characterized Vav …
WebGraphic representation of the differences in median area of vascular outgrowth (expressed as numbers of pixels × 1000) between the metatarsals cultured with and without VEGF … little black bird with orange beakWebOct 29, 2024 · The proper expression of CTGF is essential for the physiological process of multiple organs such as bone, brain, heart, and lung. CTGF knockout mice demonstrated developmental skeletal … little black book addressWebMar 13, 2014 · Connective tissue growth factor is immediately upregulated in the epithelium at the wound margin. (A) A representative 1.0-mm phototherapeutic keratectomy (PTK) … little black bits in washing machineWebJun 13, 2024 · Fibroblast-specific connective tissue growth factor (CTGF) knockout inhibits angiotensin II (Ang II)-induced skin fibrosis.a Mice skin fibroblasts from CTGF knockout … little black book antwerpenWeb030769 129S/Sv- Ccn2 tm1Mae /J These mice carry a knock-out of the Ctgf gene. As part of an allelic set, with the Ctgf Lo-Hi allele (Stock No. 030767 ), Ctgf gene expression can … little black bird with red on wingsWebMar 21, 2005 · Transforming growth factor–β (TGF-β) acts as a potent growth inhibitor of most epithelial cell types .It arrests the cell cycle in the G 1 phase thereby tightly … little black book 2022WebMar 9, 2024 · CCN family member 2, Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24) ... in knockout mice; These findings uncover a novel functional role of CCN2 as a metabolic supporter in the growth-plate chondrocytes, which is required for skeletogenesis in mammals. ... little black book app