WebJun 1, 2006 · Disruption of the Cyp4a10 gene causes hypertension. Mating and selection of germ line chimeras carrying a mutant Cyp4a10 allele were used to generate …
Did you know?
WebSymbol. Cyp4a10. Name. cytochrome P450, family 4, subfamily a, polypeptide 10. Synonyms. Cyp4a, D4Rp1, Msp-3, RP1. Feature Type. protein coding gene. IDs. WebOct 11, 2014 · CYP4A10/11/14/12A/22 Antibodies. Antibodies that detect CYP4A10/11/14/12A/22 can be used in several scientific applications, including Immunohistochemistry, ELISA, Immunocytochemistry and Western Blot. This Rabbit polyclonal antibody targets CYP4A10/11/14/12A/22 in Rat, Mouse and Human samples, …
WebDec 1, 2011 · 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR), a prodrug activator of AMP-activated protein kinase (AMPK), increased hepatic expression of cytochrome P450 4a10, 4a14, and 4a31 mRNAs 2-, 3-, and 4-fold, respectively, and liver microsomal lauric acid ω-hydroxylation increased 2.8-fold. Likewise, mRNA levels of the … WebCytochrome P450 4A11 is a protein that in humans is codified by the CYP4A11 gene. [5] [6] Function [ edit] This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other …
WebMurine Cyp4a10 and Cyp4a14 (homologous to CYP4A22 and CYP4A11 in human, respectively) are highly expressed in the liver and are known to convert the arachidonic … WebApr 15, 2000 · In Cyp2e1 –/– mice with NASH (but not in wild-type mice), CYP4A10 and CYP4A14 were upregulated. Furthermore, hepatic microsomal lipid peroxidation was …
WebSep 2, 2016 · For genes involved in fatty-acid metabolism and transportation, the expression of Fas was decreased by BBR treatment, and the expression of Cyp4a10 was upregulated significantly. The expression of Mtp and ApoB were not changed (Fig. 2, A and B). The intestinal FXR pathway plays a key role in the regulation of cholesterol metabolism and …
WebJan 12, 2014 · Cyp4a10 −/− mice on a low-salt diet had a similar hepatic acute phase response as those mice on a high-salt diet, suggesting that hypertension associated with this genotype is not the cause of their altered inflammatory response. In contrast, wild-type, Cyp4a10 −/−, and Cyp4a14 −/− mice showed similar responses to injected LPS. chirurg toruńWeb1. The CYP4 family consists of 11 subfamilies (CYP4A-CYP4M), which encode constitutive and inducible isozymes expressed in both mammals and insects. 2. The CYP4A subfamily encodes several cytochrome P450 enzymes that are capable of hydroxylating the terminal omega-carbon and, to a lesser extent, the … 1. graphisoft colombiaWebThe sequenceof this gene is defined by 4 GenBank accessions, some from liver (seen 2 times), lung (once). Alternative mRNA variants and regulation:The gene contains14 distinct gt-ag introns. Transcription produces 2 alternatively spliced mRNAs. graphisoft componentWebUnlike rosiglitazone, chiglitazar showed significant increase of mRNA expression of PPARα, CPT1, BIFEZ, ACO and CYP4A10 in the liver of MSG obese rats. Physicochemical Properties. M.Wt 594.618 Formula C36H28FN2NaO4 CAS No. 1959588-75-0 ... chirurg toracicWebJan 14, 2014 · 13117 (Cyp4a10) Enzymes [BR:mmu01000] 1. Oxidoreductases 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor 1.14.14.80 long-chain fatty acid omega-monooxygenase 13117 (Cyp4a10) chirurg treantWebNov 2, 2016 · CYP4A10 and CYP4A14 are two key enzymes for ω-oxidation of hepatic fatty acids. The effects of rifampicin on the expression of hepatic Cyp4a10 and Cyp4a14 were … chirurg transplantologWebAntibodies that detect Cyp4a10 can be used in several scientific applications, including Immunohistochemistry, Immunocytochemistry and Western Blot. This Rabbit polyclonal antibody targets Cyp4a10 in Rat, Rabbit, Human and Feline samples, and has been validated in experiments with 14 publications and 11 images featured in our data gallery. chirurg turek