http://jur.byu.edu/?p=1626 WebFeb 22, 2024 · To fill this knowledge gap, we examined the effect of intragastric and intraarticular metformin in an destabilization of the medial meniscus (DMM) model of OA in mice, known to cause destabilization of the joint which eventually leads to degeneration and pain of the joint, and investigated whether the anabolic and anti-catabolic effects of …
Kindlin-2 preserves integrity of the articular cartilage to protect ...
WebMay 1, 2024 · Conclusions. We developed medial meniscus extrusion in a rat model, and centralization of the extruded medial meniscus by the pull-out suture technique improved the medial meniscus extrusion and delayed cartilage degeneration, though the effect was limited. Centralization is a promising treatment to prevent the progression of osteoarthritis. WebJun 28, 2024 · A mouse OA model was induced using destabilization of the medial meniscus (DMM) surgery, chondrocyte ferroptosis was induced using an intra-articular injection of Erastin, and Met (200 mg/kg/day) was intragastrically administered for 8 weeks after surgery. H&E and Safranin O‑fast green staining were used to evaluate cartilage … csg template
Age-dependent Changes in the Articular Cartilage and ... - Nature
WebApr 14, 2024 · The meniscus plays a central load‐bearing role in the knee joint. Unfortunately, meniscus injury is common and can lead to joint degeneration and osteoarthritis (OA). In small animal models, progressive degenerative changes occur with the unloading of the meniscus via destabilization of the medial meniscus (DMM). WebJan 1, 2014 · The surgical model of destabilization of the medial meniscus (DMM) has become a gold standard for studying the onset and progression of posttraumatic osteoarthritis (OA). The DMM model … WebFeb 9, 2024 · Age is the primary risk factor for osteoarthritis (OA), yet surgical OA mouse models such as destabilization of the medial meniscus (DMM) used for evaluating … csg terminal